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KMID : 0363620080290020021
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Journal of Korean Oriental Medicine
2008 Volume.29 No. 2 p.21 ~ p.31
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Protective Effects of Singihwan (腎氣丸) on Traumatic Brain Injury-induced Apoptosis in Rat Hippocampal Dentate Gyrus
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Kwon Oh-Bong
Song Yun-Kyung
Lim Hyung-Ho
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Abstract
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Backgrounds: Singihwan is used “to strengthen inborn energy” and we suspected a protective effect on brain neuron cells.
Objectives: The aim of this study was to evaluate the effects of Singihwan (SGH) on traumatic brain injury-induced delayed apoptosis in rat hippocampal dentate gyrus.
Methods: For a surgical induction of traumatic brain injury (TBI), a 5 mm diameter stainless rod was used to make traumatic attack from the surface of the brain used by an impactor. The protective effect of the aqueous extract of
SGH against TBI in the rat hippocampal dentate gyrus was investigated by using step-down avoidance task, terminal
deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, Bax immunohistochemistry, and 5-bromo-2’-deoxyuridine (BrdU) immunohistochemistry.
Results: The aqueous extract of SGH suppressed the TBI-induced increase in apoptosis and cell proliferation in the hippocampal dentate gyrus.
Conclusions: It is possible that the aqueous extract of SGH has a neuroprotective effect on TBI-induced neuronal
cell death.
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KEYWORD
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Singihwan, hippocampal dentate gyrus, apoptosis, traumatic brain injury
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